Changes in RFamide-Related Peptide-1 (RFRP-1)-Immunoreactivity During Postnatal Development and the Estrous Cycle

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Expression of RFamide-related peptide in the dorsomedial nucleus of hypothalamus during the estrous cycle of rats

Introduction: RFamide-related peptide (RFRP) is believed to act as an inhibitor of gonadotropin releasing hormone (GnRH) secretion. The aim of the present study was to compare the expression pattern of RFRP neurons in the dorsomedial nucleus of hypothalamus (DMH) at different phases of the rat estrous cycle. Methods: The phases of the estrous cycle were determined in 16 adult female Sprague-...

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Hypothalamic Expression of KiSS1 and RFamide-related Peptide-3 mRNAs during The Estrous Cycle of Rats

Kisspeptin and RFamide-related peptide-3 (RFRP-3) are known to affect GnRH/luteinizing hormone (LH) in several species, including the rat. It has been hypothesized that GnRH/LH changes during the rat estrous cycle may result from changes in the expression of KiSS1 and RFRP-3 genes. Therefore, the present study investigates KiSS1 and RFRP-3 gene expression at the transcriptional level in the rat...

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ژورنال

عنوان ژورنال: Endocrinology

سال: 2014

ISSN: 0013-7227,1945-7170

DOI: 10.1210/en.2014-1274